Steroidal saponins from paris polyphylla var. yunnanensis

A disease similar to systemic lupus erythematosus (SLE) has been observed in monkeys fed alfalfa seeds. 26 The disease was characterized by hemolytic anemia, decreased serum complement levels, immunologic changes, and deposition of immunoglobulins in the kidney and skin. Alfalfa ingestion has resulted in pancytopenia and hypocomplementenemia in healthy subjects. 27 L-canavanine has been implicated as the possible causative agent. The toxicity of L-canavanine is mainly due to its structural similarity to arginine. Canavanine binds to arginine-dependent enzymes interfering with their action. Arginine reduces the toxic effects of canavanine in vitro. 28 Further, canavanine may be metabolized to canaline, an analog of ornithine. Canaline may inhibit pyridoxal phosphate and enzymes that require the B 6 cofactor. 14 L-canavanine has also been shown to alter intercellular calcium levels 29 and the ability of certain B or T cell populations to regulate antibody synthesis. 30 , 31 Alfalfa tablets have been associated with the reactivation of SLE in at least 2 patients. 32

Steroidal saponins from paris polyphylla var. yunnanensis

steroidal saponins from paris polyphylla var. yunnanensis

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