Hello Chris Wallace or SARMSstore comments moderator:
I have some champion Siberian Huskies, they are record holders in pushing and pulling competitions for dogs. I would like to provide them with a boost in strength for their next events. I was going to try LG-4033. I have a couple of 220 lbs huskies and three 132 lbs female huskies. I was going to give the males 10mg and the females 5mg. Does this sound about right. Also, I keep reading about cycling. As I understand cycling as it applies to oral testosterones that is because of the alkyd molecule at the 17a position which caused liver damage but allowed the testosterone to make multiple passes thru the liver.
Since LG-4033 is a SARMS, there is no Alkyd molecule to cause liver dysfunction, correct? Is it really necessary to cycle the SARMS then? I really care about my Huskies and only want the best for them.
These are serious questions and I hope you take the time to respond.
Thanks, Husky Trainer.
Enzalutamide has greater affinity to AR than Bicalutamide does in a competition assay with 16β-[ 18 F]fluoro-5α-DHT (18-FDHT) in castration-resistant LNCaP/AR cells (AR-overexpressing). While Enzalutamide shows no agonism in LNCaP/AR prostate cells. Enzalutamide antagonizes induction of prostate-specific antigen (PSA) and transmembrane serine protease 2 (TMPRSS2), combination with the synthetic androgen R1881 in parental LNCaP cells. Enzalutamide could inhibit the transcriptional activity of a mutant AR protein (W741C, mutation of Trp 741 to Cys).  Enzalutamide also prevents nuclear translocation and co-activator recruitment of the ligand-receptor complex. 
Neural injections of Bromodeoxyuridine (BrdU) were applied to males of both groups to test for neurogenesis . Analysis showed that testosterone and dihydrotestosterone regulated adult hippocampal neurogenesis (AHN). Adult hippocampal neurogenesis was regulated through the androgen receptor in the wild-type male rats, but not in the TMF male rats. To further test the role of activated androgen receptors on AHN, flutamide , an antiandrogen drug that competes with testosterone and dihydrotestosterone for androgen receptors , and dihydrotestosterone were administered to normal male rats. Dihydrotestosterone increased the number of BrdU cells, while flutamide inhibited these cells.