Side effects of prolonged steroid therapy

Less common side effects are bleeding gums, breakthrough vaginal bleeding, vaginal spotting, changes in menstrual flow, painful menstruation. pre-menstrual syndrome, no menstrual period during and after estrogen use, enlargement of uterine fibroids, vaginal infection with Candida, a cystitis-like syndrome, mild diarrhea, jaundice or yellowing of the skin or whites of the eyes, rash, loss of scalp hair, and development of new hairy areas. Lesions of the eye and contact-lens intolerance have also been associated with estrogen therapy. You may experience migraine headache, mild dizziness, depression, and increased sex drive (women) or decreased sex drive (men).

Neoplasms: Liver (hepatic hemangiosarcoma, liver cell adenoma , hepatocellular carcinoma ); breast (fibrocystic disease, breast carcinoma ); endometrium (endometrial carcinoma); nervous system ( astrocytoma , pituitary tumor, prolactinoma, neurofibromatosis , glioblastoma multiforme , brain abcess); ovary (luteoma of pregnancy, dermoid cyst of the ovary , ovarian carcinoma); trophoblastic (hydatiform mole, choriocarcinoma ); miscellaneous ( melanoma , myeloma , perianal cysts, renal cell carcinoma , Hodgkin’s lymphoma , tongue carcinoma, bladder carcinoma)

Amphetamines have been extensively abused. Tolerance, extreme psychological dependence, and severe social disability have occurred. There are reports of patients who have increased the dosage to levels many times higher than recommended. Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG . Manifestations of chronic intoxication with amphetamines include severe dermatoses, marked insomnia, irritability, hyperactivity , and personality changes. The most severe manifestation of chronic intoxication is psychosis , often clinically indistinguishable from schizophrenia .

Aripiprazole lauroxil Extended-Release IM Suspension:
Frequency not reported: Angina pectoris , orthostatic hypotension , palpitations , tachycardia

Aripiprazole Extended/Prolonged-Release IM Suspension:
Common (1% to 10%): Hemorrhage, hypertension
Uncommon (% to 1%): Abnormal electrocardiogram, bradycardia , chest discomfort, decreased blood pressure, electrocardiogram QT prolonged, electrocardiogram T-wave abnormal/amplitude decreased/inversion, increased blood pressure, orthostatic hypotension, peripheral edema, tachycardia, ventricular extrasystole
Rare (% to %): Sinus tachycardia
Frequency not reported: Acute myocardial infarction, cardiac arrest , chest pain, congestive cardiac failure, contusion, decreased heart rate, deep vein thrombosis , first-degree atrioventricular block, orthostatic hypertension, Torsade de pointes, venous thromboembolism , ventricular arrhythmias

Immediate-Release IM Injection:
Common (1% to 10%): Tachycardia
Uncommon (% to 1%): Increased diastolic blood pressure, orthostatic hypotension
Frequency not reported: Angina pectoris, atrial fibrillation , atrial flutter , atrioventricular block, bradycardia, cardiac arrest, cardiopulmonary failure, cardiorespiratory arrest, chest pain, deep vein thrombosis, electrocardiogram QT prolonged, hypertension, hypotension, myocardial infarction, myocardial ischemia, palpitations, peripheral edema, QT prolongation, Torsade de pointes, venous thromboembolism , ventricular arrhythmia

Oral Formulations:
Common (1% to 10%): Chest pain, hypertension, peripheral edema
Uncommon (% to 1%): Angina pectoris, atrial fibrillation, atrioventricular block, bradycardia, cardiopulmonary failure, cardiorespiratory arrest, chest discomfort, edema, electrocardiogram QT prolonged, extrasystole, generalized edema, heart rate increased, hot flush, hypotension, myocardial infarction, myocardial ischemia, orthostatic hypotension, sinus tachycardia, tachycardia
Rare (% to %): Atrial flutter, electrocardiogram abnormal, electrocardiogram PR prolongation, electrocardiogram T wave inversion, flushing, heart rate irregular, hyperemia, supraventricular tachycardia , ventricular tachycardia
Frequency not reported: Cardiac arrest, deep vein thrombosis, hypotension, palpitations, Torsade de pointes, venous thromboembolism, ventricular arrhythmias [ Ref ]

Side effects of prolonged steroid therapy

side effects of prolonged steroid therapy

Aripiprazole lauroxil Extended-Release IM Suspension:
Frequency not reported: Angina pectoris , orthostatic hypotension , palpitations , tachycardia

Aripiprazole Extended/Prolonged-Release IM Suspension:
Common (1% to 10%): Hemorrhage, hypertension
Uncommon (% to 1%): Abnormal electrocardiogram, bradycardia , chest discomfort, decreased blood pressure, electrocardiogram QT prolonged, electrocardiogram T-wave abnormal/amplitude decreased/inversion, increased blood pressure, orthostatic hypotension, peripheral edema, tachycardia, ventricular extrasystole
Rare (% to %): Sinus tachycardia
Frequency not reported: Acute myocardial infarction, cardiac arrest , chest pain, congestive cardiac failure, contusion, decreased heart rate, deep vein thrombosis , first-degree atrioventricular block, orthostatic hypertension, Torsade de pointes, venous thromboembolism , ventricular arrhythmias

Immediate-Release IM Injection:
Common (1% to 10%): Tachycardia
Uncommon (% to 1%): Increased diastolic blood pressure, orthostatic hypotension
Frequency not reported: Angina pectoris, atrial fibrillation , atrial flutter , atrioventricular block, bradycardia, cardiac arrest, cardiopulmonary failure, cardiorespiratory arrest, chest pain, deep vein thrombosis, electrocardiogram QT prolonged, hypertension, hypotension, myocardial infarction, myocardial ischemia, palpitations, peripheral edema, QT prolongation, Torsade de pointes, venous thromboembolism , ventricular arrhythmia

Oral Formulations:
Common (1% to 10%): Chest pain, hypertension, peripheral edema
Uncommon (% to 1%): Angina pectoris, atrial fibrillation, atrioventricular block, bradycardia, cardiopulmonary failure, cardiorespiratory arrest, chest discomfort, edema, electrocardiogram QT prolonged, extrasystole, generalized edema, heart rate increased, hot flush, hypotension, myocardial infarction, myocardial ischemia, orthostatic hypotension, sinus tachycardia, tachycardia
Rare (% to %): Atrial flutter, electrocardiogram abnormal, electrocardiogram PR prolongation, electrocardiogram T wave inversion, flushing, heart rate irregular, hyperemia, supraventricular tachycardia , ventricular tachycardia
Frequency not reported: Cardiac arrest, deep vein thrombosis, hypotension, palpitations, Torsade de pointes, venous thromboembolism, ventricular arrhythmias [ Ref ]

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