Marquardt defeated Rousimar Palhares via TKO (punches) at 3:28 of round 1 at the main-event of UFC Fight Night 22. During the fight Palhares went for a heel-hook however Marquardt slipped his leg free and quickly turned the tables for a first-round TKO victory. However, this came with some controversy. Once Marquardt pulled his leg free, Palhares looked at his hand and signalled to officials and seemingly complained that Marquardt was greased. Marquardt capitalized on the opening and pounded Palhares with a quick barrage of punches. The ending, though, wasn't due to any illegal circumstances. UFC broadcaster Joe Rogan immediately announced that Marquardt had passed an inspection from the ringside physician and the referee. Marquardt explained that before the fight; "I came out really warm because I wanted a good sweat," which explains why he was slippery and managed to remain elusive.    Marquardt’s trainer Greg Jackson stated that officials checked Marquardt before the fight for any greasing type substance. 
On March 25, 2010 Thiago Alves was removed from the card due to brain irregularity from a pre-fight CAT scan.  After learning of the removal, Ben Saunders , who was scheduled to fight Jake Ellenberger , requested Alves's opponent, Jon Fitch , and subsequently replaced Ellenberger on the card. As a result, Ellenberger did not compete but received his "show" and "win" money to make up for the last minute switch.  The fight between Kurt Pellegrino and Fabricio Camoes was moved up to the main card as a result of the cancellation.