Ligand binding domain of steroid hormone receptors

Evidence for crosstalk between the extrinsic and intrinsic pathways exists in the Fas signal cascade. In most cell types, caspase-8 catalyzes the cleavage of the pro-apoptotic BH3 -only protein Bid into its truncated form, tBid. BH-3 only members of the Bcl-2 family engage exclusively anti-apoptotic members of the family (Bcl-2, Bcl-xL), allowing Bak and Bax to translocate to the outer mitochondrial membrane, thus permeabilizing it and facilitating release of pro-apoptotic proteins such as cytochrome c and Smac/DIABLO , an antagonist of inhibitors of apoptosis proteins ( IAPs ).

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Ligand binding domain of steroid hormone receptors

ligand binding domain of steroid hormone receptors

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ligand binding domain of steroid hormone receptorsligand binding domain of steroid hormone receptorsligand binding domain of steroid hormone receptorsligand binding domain of steroid hormone receptorsligand binding domain of steroid hormone receptors

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