Evidence for crosstalk between the extrinsic and intrinsic pathways exists in the Fas signal cascade. In most cell types, caspase-8 catalyzes the cleavage of the pro-apoptotic BH3 -only protein Bid into its truncated form, tBid. BH-3 only members of the Bcl-2 family engage exclusively anti-apoptotic members of the family (Bcl-2, Bcl-xL), allowing Bak and Bax to translocate to the outer mitochondrial membrane, thus permeabilizing it and facilitating release of pro-apoptotic proteins such as cytochrome c and Smac/DIABLO , an antagonist of inhibitors of apoptosis proteins ( IAPs ).
A search function with extensive filter options allows you to quickly identify the most suitable product amongst the large product range on antibodies-. You may for instance start by entering the antigen name of the target you are interested in. The search results can be refined by setting filters for product type, reactivity, host and others. For example, if you are looking for an ELISA kit for the measurement of Interleukin 6 in rat material, you can enter the antigen name, set a filter for the reactivity “rat” and select the product type “kit” as well as the application “ELISA”. For information about our independent validation initiative please visit our IV blog .