Formulation considerations of intranasal corticosteroids for the treatment of allergic rhinitis

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Feed formulation requires in-depth knowledge of animal nutrition, particularly the nutrient requirements and the nutrient composition of the ingredients. It also requires nutritionists to know whether using certain proportions of some ingredients will impact on issues such as feed flow through the mill, pellet quality of the diet, response of the diet to feed additives, or gut health of the animal. In some parts of the world, considerations such as the colour, smell and particle size of the feed are viewed as important by the feed buyer, despite that these factors may have little influence on the nutritional quality of the feed. Ultimately, feed formulation is about economics; for some operations, it probably means the best feed conversion efficiency of the animal, whereas for others it perhaps means least cost per unit of product output.

By the time phase III clinical trials are reached, the formulation of the drug should have been developed to be close to the preparation that will ultimately be used in the market. A knowledge of stability is essential by this stage, and conditions must have been developed to ensure that the drug is stable in the preparation. If the drug proves unstable, it will invalidate the results from clinical trials since it would be impossible to know what the administered dose actually was. Stability studies are carried out to test whether temperature , humidity , oxidation , or photolysis ( ultraviolet light or visible light ) have any effect, and the preparation is analysed to see if any degradation products have been formed.

Formulation considerations of intranasal corticosteroids for the treatment of allergic rhinitis

formulation considerations of intranasal corticosteroids for the treatment of allergic rhinitis

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