Its action in the male body is like that of LH, stimulating the Leydig cells in the testes to produce testosterone even in the absence of endogenous LH. HCG is therefore used during longer or heavier steroid cycles to maintain testicular size and condition, or to bring atrophied (shrunken) testicles back up to their original condition in preparation for post-cycle Clomid therapy. This process is necessary because atrophied testicles produce reduced levels of natural testosterone, this situation should be rectified prior to post-cycle Clomid therapy.
Saliva testing and capillary dried blood spot testing presents such an answer. Discerning between free and protein bound hormones is especially important when monitoring topical or transdermal hormone therapy. When hormones are delivered through the skin as supplements the capillary dried blood spot hormone level rises in concert with the increase in salivary hormone levels because hormone delivery to all tissues is well represented. Blood taken by conventional venipuncture rises very little not at all or even decreases in some cases with skin delivery of hormones. This might seem odd but blood being delivered back to the heart through the veins has already delivered its bioavailable hormone load and hormones remaining in the bloodstream are tightly bound to serum proteins such as SHBG and albumin.