Although I am usually not inclined to posit speculations on why a particular drug does or doesn't do something, in this case I will. Im guessing that the higher doses of Anadrol cause enough appetite suppression (at least anecdotally) to make eating rather difficult. It can also increase insulin resistance and glucose intolerance (5). This has the effect of making macronutrient absorption more inefficient, and could also be a factor in reducing gains when the dosage goes over 100mgs/day. Unfortunately, Anadrol also has a reasonably profound effect on your body's natural hormonal system, on par with most other oral steroids , but not as bad as most injectables, and its certainly not as harsh on your lipid profile as many anabolics are
Dianabol is not an extremely androgenic steroid, its androgenicity has been structurally reduced, but androgenic side effects are still possible. Such side effects of Dianabol use include acne, accelerated hair loss in those predisposed to male pattern baldness and body hair growth. Most men should not have a problem with such effects, response will be the final dictator, but most will remain clear. Although the odds are in your favor, such effects are brought on by Methandrostenolone being metabolized by the 5-alpha reductase enzyme. This is the same enzyme responsible for the reduction of testosterone to dihydrotestosterone, but the overall conversion here will result in very low amounts of dihydromethandrostenolone. This tells us 5-alpha reductase inhibitors like Finasteride that are often used to combat androgenic side effects will have very little if any affect on Dianabol.
Despite its reduced androgenicity, Dianabol can promote virilization symptoms in women. Such symptoms include body hair growth, a deepening of the vocal chords and clitoral enlargement. It is possible for some women to use this steroid without virilization symptoms with extremely low doses, but the odds are not favorable. Most all women should choose anabolic steroids with less translating androgenic activity to meet their needs.
Trenbolone also has progestagenic affects. Tren, as we’ve previously said, possesses strong androgenic properties. Tren is not known in the anabolic steroid community to cause gyno. However, it would be interesting to observe many cycles of anabolic steroids which include a heavily aromatizing steroid with trenbolone. No doubt many athletes have combined tren and testosterone with miraculous results. It would be interesting to note amongst these individuals if they have ever developed gyno when combining the drugs, but not when taking them alone. Remember, progesterone sensitizes the body to estrogen, so whatever estrogen is available will be more likely to act out and cause the negative effects we know estrogen is responsible for. The moral of the story is to be cautious and knowledgeable about the drugs you are combining. Actually, that should be true whether you are 21 and raving at a night club on e, or a responsible individual, through with your party stage, and maximizing your safe use of anabolic steroids. Drug synergy can be an amazingly useful tool when used for maximal gain, but can be very unfortunate and even dangerous if multiple negative properties of drugs are allowed to gather inside the body. We will talk more about the specifics of drug synergy in another section.