Due to a wide range of media coverage and large scale steroid scandals fans and experts have continued to bring the games integrity into question. Major League Baseball is a game of statistics. The entirety of a player's career is based upon the consistency and credibility of the numbers and accolades acquired during the period in which they played. "Their real impact has been at the margins: There are certainly some scrubs who wouldn't be in the majors without the juice, and we have ample evidence that at the other end of the scale, drugs can take Hall of Famers and all-time greats and help them perform at historically unprecedented levels" (La-Times). When it comes to this topic generally there are two trains of thought. Many do not see the harm with this type of substance use because it makes the game more exciting and allows athletes to reach untested potentials. On the other side of the argument many fans and experts believe the game has lost its purity because of this drug use. More recently an issue has arose with high-caliber players who have tested positive for performance-enhancing drugs are not being voted for on a hall of fame ballot. This fact has brought many to question the game's integrity. No matter the statistics and achievements produced by the certain player prior to drug use, a positive test for steroids has shown to discredit the athletes integrity and career entirely.
Figure 3. Origin of the endomembrane hypothesis. a) Eukaryotes emerged from an ancestral archaean cell. DNA is some prokaryotes are concentrated within the cell, in an area known as a nucleoid. b) The cell membrane of the ancestral archaean cell began to infold on itself forming plasma membrane within the cell. We see this in certain species of bacteria, and in some cases these infolding isolate the nucleiod.. c) The first true nucleus formed with the infoldings separated from the cell membrane, and encased the chromosomes, creating a nuclear envelope. The endoplasmic reticulum is physically connected to the nuclear envelope, yet reaches out into the cytoplasm of the cell. Additional organelles of the endomembrane system include the Golgi apparatus, vesicles and lysosomes.